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pentobarbital will lessen the extent or effect of lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with strong CYP3A4 inducers can lead to lessened serum concentrations and loss of antimalarial efficacypentobarbital will lower the extent or outcome of dienogest/estradiol valerate by affectin